Relationships between parenteral nutrition and clinical outcomes v1.1

• Research type

  Research Study

• Full title

  An exploration of the potential relationships between parenteral nutrition and clinical outcomes in Short Bowel Syndrome patients at Salford Royal NHS Foundation Trust

• IRAS ID

  181968

• Contact name

  Sorrel Burden

• Contact email

  sorrel.burden@manchester.ac.uk

• Sponsor organisation

  Salford Royal NHS Foundation Trust

• Duration of Study in the UK

  0 years, 2 months, 28 days

• Research summary

  Short bowel syndrome (SBS) is a type of bowel failure that is rare and causes weakness in those diagnosed. SBS usually happens because an operation, disease or injury causes the bowel to stop working properly or causes sufferers to lose parts of the bowel. Patients experience a reduction in digestion of food and/or water and key minerals. Supplementary feeding through a vein (parental nutrition) can be used in people with SBS so that eating and good health can continue. In addition interventions can be given that make the patient’s bowel bigger or slow food movement allowing it to be taken in through the bowel. If change of the bowel does not happen then bowel failure may become permanent. This means patients require vein feeding for the rest of their life. However, delivering feed though a vein is not without problems and patient can experience blood infection, administration problems and liver changes. The aim of this study is to look at possible links between feeding by a vein and medical outcomes.
  This study will use existing patient clinical records for Salford Royal patients with SBS who have received parental feeding, to explore whether any links exist between treatment and outcomes. We will examine the records of all patients who have received treatment from 2011 onwards. Key pieces of clinical information will be brought together and matched with patients feeding prescriptions. Information about the amount and make-up of the feed, and number of times feed is given will be recorded. These will be matched to patient results such as administration problems and hospital admissions, and other health events will be examined. By undertaking the study we aim to identify previously unknown relationships between the type of feed and feeding schedule, and patient’s problems. This information will help inform further studies and practice.

• REC name

  HSC REC A

• REC reference

  15/NI/0112

• Date of REC Opinion

  4 Jun 2015

• REC opinion

  Favourable Opinion