Regulation of innate lymphoid cells
Research type
Research Study
Full title
Investigation of BET-inhibitors in the regulation of innate lymphoid cells.
IRAS ID
169508
Contact name
Andrew McKenzie
Contact email
Sponsor organisation
MRC Laboratory of Molecular Biology
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
The lining of an airway is protected by a layer of cells called the epithelium. Following allergen challenge the cells of the epithelium release small proteins called cytokines which affect the behaviour of nearby cells, including innate lymphoid cells (ILCs). These ILCs are activated by the epithelium-derived cytokines and the ILCs themselves then produce further cytokines, resulting in amplification of the immune response.
ILCs are categorised into three broad categories which in part is based upon the cytokines that they release when activated.
Inhibition of ILCs may represent prospective therapies for ameliorating inappropriate immune responses such as occurs in asthma. This research project aims to test inhibitors in a range of assays to investigate their efficacy at inhibiting ILC function. ILC were only recently discovered and little is known about them in humans.REC name
London - Hampstead Research Ethics Committee
REC reference
15/LO/0321
Date of REC Opinion
12 Feb 2015
REC opinion
Favourable Opinion