Regulation of Gene Expression and DNA Repair in Haematological Disease
Research type
Research Study
Full title
Regulation of Gene Expression and the DNA Damage Response in Acute Leukaemia, Pre-Leukaemia and in Haematopoietic Stem Cell Transplantation
IRAS ID
342904
Contact name
Sandeep Potluri
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
30 years, 0 months, 1 days
Research summary
It is not well understood why children develop acute leukaemias. Some children have known mutations in pathways affecting DNA repair or in gene expression and are said to have 'leukaemia predisposition syndromes'. However, it is not known how these mutations lead to cancer and if there are therapeutic ways of preventing that from happening. In addition, once a patient with leukaemia pre-disposition has developed acute leukaemia, treating them with conventional chemotherapeutic agents or doing a conventional bone marrow transplant is associated with a lot or morbidity and mortality (Reviewed in Vissers et al., JCM 2023 and de Latour et al., Blood 2016). Consequently, there is a need to collect blood and marrow samples from such patients in order to understand molecular mechanisms and whether more targeted treatment can be achieved.
REC name
London - Bromley Research Ethics Committee
REC reference
25/PR/0245
Date of REC Opinion
6 Jun 2025
REC opinion
Further Information Favourable Opinion