REGULATE
Research type
Research Study
Full title
REGULATE - Relationship between Glucose profile, infarct morphology and clinical outcome in patients with ST-elevation myocardial infarction (STEMI)
IRAS ID
264339
Contact name
John P Greenwood
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
People with diabetes who have a heart attack generally do less well than those without diabetes. This has changed little over the years despite advances in heart attack treatment. This suggests that more effective diabetes-related management strategies are required after a heart attack.\n\nLooking at glucose control we mainly use single blood sugar measurements or an HbA1c test. A single blood sugar only measures glucose at one time point and does not show acute glucose swings. HbA1c shows long term glucose control over 2-3 months but also does not show acute changes. In reality glucose control is dynamic, with glucose tolerance and insulin sensitivity varying across the day and night.\n\nIn this study we will use Continuous Glucose Monitoring (CGM) with a small stick-on patch that measures a person’s sugar level every 5 minutes, day and night. We will look at the relationship between the glucose control as measured by the patch and the findings of the heart MRI scan, in particular the effect of the heart attack on the heart muscle. The study will enrol both diabetic and non-diabetic patients to explore the differences in CGM profiles between those 2 groups.\nThis will be a pilot study to gather information which will hopefully lead to further work in this area.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
19/YH/0163
Date of REC Opinion
10 Jul 2019
REC opinion
Favourable Opinion