RegenBro
Research type
Research Study
Full title
Regenerative medicine therapy of Bronchopulmonary dysplasia
IRAS ID
210337
Contact name
Jessica Bratt
Contact email
Sponsor organisation
Keele University
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
Bronchopulmonary dysplasia (BPD) is the commonest chronic lung disease in babies. It can be present in up to a quarter of prematurely born babies who require prolonged oxygen therapy. There is no effective treatment for BPD as little is known about the underlying mechanism. Stem cells may have important roles in the management of BPD. We would like to see the effects of stem cells and/or stem cell conditioned media, containing secreted molecules, on the cells from babies with BPD compared to those from babies without BPD.
We plan to collect cells from the following groups:
1. Washings from routine suction of babies who are being ventilated, in different age groups. These washings are normally considered as waste products.
2. Nasal brushings from ventilated or non-ventilated babies admitted to neonatal intensive care unit.
3. Nasal brushings from 4-12 week old babies attending hospital clinics.Consent will be taken from a parent of the babies. Cells will be expanded using in vitro cell culture techniques to obtain sufficient numbers for experimentation. These expanded cells will be incorporated into collagen and elastin gels and their behaviour will be assessed when exposed to insults that are know to provoke a BPD phenotype. The ability of the stem cells and/or stem cell conditioned media to change this behaviour will be determined.
REC name
Wales REC 7
REC reference
16/WA/0265
Date of REC Opinion
29 Sep 2016
REC opinion
Further Information Favourable Opinion