Redox State of Centenarians of the SWISS100 Study v1
Research type
Research Study
Full title
Redox State of Centenarians of the Swiss Centenarian Study
IRAS ID
357607
Contact name
Martin Feelisch
Contact email
Sponsor organisation
University of Southampton
Clinicaltrials.gov Identifier
103237, ERGO Submission ; CRS115_186239, Swiss National Science Foundation Sinergia project number
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The increase in life expectancy translates into a rapid growth of the ageing population in most parts of the world, presenting both opportunities and challenges. Although health and agility can vary considerably between individuals, centenarians have been considered a model of ‘successful agers’. The Swiss Centenarian (SWISS100) study was designed to identify specific characteristics and challenges of Centenarians living in Switzerland using a holistic multi-disciplinary approach. Specifically, this study aims to identify profiles of vulnerability (individuals’ susceptibility to stressors) and resilience (individuals’ ability to maintain functioning when confronted with adversity) of centenarians. Swiss centenarians were recruited to participate in multiple assessments to understand how the combination of cognitive function, social relationships and networks as well as their physical and mental health, determines their vulnerability and resilience. In addition to those assessments, blood samples were collected and processed between 2020 and 2024 from 126 Swiss centenarians, and control participants (116 geriatric patients and 139 young healthy volunteers) living in Geneva, Zurich and Ticino, Switzerland. In order to provide novel insight into ageing trajectories and identify hallmarks of resilience those blood samples were separated into plasma, serum and red blood cells aliquots of which will be shipped to and analysed for specific redox and metabolic biomarkers at the University of Southampton. Together with the proteomic and physiological analyses carried out in Switzerland this should enable the identification of novel patterns associated with successful and poor ageing.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
25/ES/0049
Date of REC Opinion
18 Jun 2025
REC opinion
Favourable Opinion