REDDS: study 2
Research type
Research Study
Full title
A Randomised Feasibility n-of-1 Trial of Weekly-Interval Red Cell Transfusion in myelodysplastic syndromes
IRAS ID
265147
Contact name
Andrew Charlton
Contact email
Sponsor organisation
The Newcastle upon Tyne Hospital NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Current standard of transfusion care in transfusion-dependent MDS is based on a policy for regular RBC transfusions that is typically multiple (2-4) units every 3-4 weeks. However, it is equally plausible that an alternative strategy, specifically lower dose and weekly transfusions of red cells, is more effective and acceptable, avoiding the Hb peaks, and particularly the troughs, of the current strategy.
This two-part study will firstly compare a patient’s usual transfusion regimen against a novel weekly transfusion schedule using matched red cells, and assess a range of patient-reported QoL and functional outcomes to provide stable estimates including range and standard deviation.
Secondly, patients and staff will also be offered the opportunity by their treating clinician to take part in a qualitative study to explore their experiences of this new weekly transfusion strategy. This will incorporate completion of semi-structured individual interviews (for patients) and focus group discussions (for staff).
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
20/NE/0097
Date of REC Opinion
20 Jul 2020
REC opinion
Further Information Favourable Opinion