Rectal Cancer Oncological Complete Response Database (OnCoRe)

• Research type

  Research Database

• IRAS ID

  232110

• Research summary

  Rectal Cancer Oncological Complete Response Database (OnCoRe)

• REC name

  West Midlands - South Birmingham Research Ethics Committee

• REC reference

  17/WM/0343

• Date of REC Opinion

  2 Oct 2017

• REC opinion

  Favourable Opinion

• Data collection arrangements

  This database will store data on patients who have been diagnosed with rectal cancer and treated with pre-operative radiotherapy or chemo-radiotherapy. In 10-20% of patients, this treatment results in a complete disappearance of the rectal tumour (known as a complete response) and it is data for these patients that we will be focusing on. Patients included will mainly be from four neighbouring cancer networks; Greater Manchester; Merseyside; North Wales; and Lancashire/South Cumbria.

  In order to compare the outcomes of these patients to those who do not experience a complete response, data for patients with rectal cancer who are treated by the usual surgical treatment will also be collected.

  Data for over 1,000 patients will be included from three previously registered audits at The Christie NHS Foundation Trust. Additionally, new patients will be added to the database as they are found to have a complete response, with their follow up and outcomes regularly updated.

• Research programme

  This research that is made possible by the data stored within this database will support all patients with rectal cancer who have a clinical complete response to chemo-radiotherapy or radiotherapy and managed by watch-and-wait (with avoidance of major surgery) – a novel management strategy for this cancer.

• Research database title

  Rectal Cancer Oncological Complete Response Database (OnCoRe)

• Establishment organisation

  The Christie NHS Foundation Trust

• Establishment organisation address

  Wilmslow Road

  Manchester

  M20 4BX