RECOVERY-Supportive Care [COVID-19] [UPH]

  • Research type

    Research Study

  • Full title

    Ventilation Strategies in COVID-19; CPAP, High-flow, and standard care



  • Contact name

    Gavin Perkins

  • Contact email

  • Sponsor organisation

    University of Warwick

  • ISRCTN Number


  • Duration of Study in the UK

    1 years, 6 months, 0 days

  • Research summary

    COVID-19 can cause serious breathing difficulties and it is important to provide artificial methods to help the patient to breathe. This study will compare three different ways of providing respiratory support to patients suspected or confirmed of having COVID-19 to see which work best. All three methods are currently in use in clinical practice and patients will receive one of these, chosen at random: 1) High Flow Nasal Oxygen (HFNO); 2) Continuous Positive Airway Pressure (CPAP); 3) Normal care involving regular oxygen therapy. Up to around 4000 patients will be included in the study from 60+ hospital sites. It will look at which treatment is more effective in relation to survival of patients and the need for intubation (tube inserted in to patient’s throat to help them breathe). It will also look at how long it takes to intubate a patient, time to death, survival rate in critical care, and the length of stay, both in critical care and overall over a 30 day period, or until the patient leaves hospital (whichever comes later). [Study relying on COPI notice]

  • REC name

    London - Brighton & Sussex Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    2 Apr 2020

  • REC opinion

    Favourable Opinion

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