Recovery in community-acquired pneumonia - An exploratory study
Research type
Research Study
Full title
Recovery in adult patients hospitalised with community-acquired pneumonia - an exploratory study
IRAS ID
242481
Contact name
Maria Koufali
Contact email
Sponsor organisation
Nottingham University Hospitals NHS Trust
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
Community-acquired pneumonia (CAP) is a common infectious illness affecting patients in the community and often leading to hospital admission. Most hospitalised patients are discharged home to continue their recovery after a brief inpatient stay. Symptoms can persist for many weeks following discharge, impacting a patients quality of life and daily activity.
The majority of research in CAP has focused on diagnosis and management, with only a small number of studies investigating CAP recovery. The conducted studies have not been consistent in their approach, using a variety of tools to measure recovery in different patient groups. There is a poor understanding of a) what normal recovery is, b) the relationship between patient-reported symptoms and markers of illness such as blood tests or lung function tests, c) the mechanisms that underlie normal and impaired recovery, and d) possible intervention that may improve recovery.
This study aims to describe recovery following discharge from hospital in 20 participants diagnosed with CAP. Participants will be assessed using several different tools across multiple different areas including patient-reported symptoms, functional activity, exercise tolerance, lung function, memory, blood markers, and x-ray changes.
The objectives are, a) to systematically and comprehensively describe recovery, and b) to determine which of the tools used to measure recovery in each domain is the most suitable, accurate, and tolerable.
It is anticipated that this exploratory study will identify which tools and approaches should be used in larger studies of CAP recovery. Defining a consistent approach to investigating recovery in CAP will allow the development of evidence to influence international guidelines for CAP management, including the identification of novel targets for new interventions, eventually reducing burden of disease for patients.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
18/WM/0117
Date of REC Opinion
23 Apr 2018
REC opinion
Favourable Opinion