Recovery from ICUAW following Severe Respiratory and Cardiac Failure.
Research type
Research Study
Full title
Prospective observational study regarding the determinants of functional disability and quality of life in patients recovering from intensive care unit-acquired weakness (ICUAW) and severe acute cardiac or respiratory failure and who require extracorporeal membrane oxygenation (CLEVERER).
IRAS ID
241375
Contact name
Mark Griffiths
Contact email
Sponsor organisation
Barts Health
Duration of Study in the UK
2 years, 10 months, 2 days
Research summary
Severe cardiac and respiratory failure can both be supported with mechanical cardiac support including treatments such as extracorporeal membrane oxygenation (ECMO). Therefore referral for this intervention can be used as a marker of the severest form of cardio-respiratory failure. Both conditions are associated with a high incidence of collateral multi-organ dysfunction and mortality; as well as long-term morbidity, loss of independence and reduced quality of life. One such organ failure, intensive care unit-acquired weakness (ICUAW) is contributed to by muscle wasting during critical illness. It can be quantified non-invasively by measuring muscle bulk and strength. Risk factors for ICUAW include sepsis (infection), immobility, hyperglycaemia and the adverse effects of drugs, specifically sedation and paralyzing agents. The interactions between the severity of illness and patient outcomes during recovery from ICUAW has been little studied. The purpose of this study is to fill a research gap and accurately identify markers that identify patients as being susceptible to ICUAW and inadequate recovery from there.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
18/LO/1682
Date of REC Opinion
21 Dec 2018
REC opinion
Further Information Favourable Opinion