Recellularisation of tissue allografts (2)
Research type
Research Study
Full title
Research and development of methods for the recellularisation of tissue allografts
IRAS ID
155283
Contact name
E Ingham
Contact email
Sponsor organisation
University of Leeds
Research summary
NHSBT Tissue Services together with colleagues from the University of Leeds have developed methods to remove donor cells from allogeneic tissue grafts without damaging the tissue matrix (decellularisation). This method has been successfully applied to a range of different human tissues.
When these decellularised grafts are implanted in patients it is anticipated that some will become recolonised by the patient’s cells very rapidly and efficiently. Other types of graft may fail to recolonise with endogeneous cells due to the thickness of the tissue (e.g. tendon) or the nature (eg size) of the implanted site. In these cases it may be necessary to seed the acellular grafts with autologous cells prior to implantation. The aim of this study is to explore different methods for seeding human cells onto decellularised human dermis, tendon, bone and amnion with a view to determining the most appropriate cell seeding method for future clinical applications.REC name
London - Westminster Research Ethics Committee
REC reference
14/LO/1269
Date of REC Opinion
7 Jul 2014
REC opinion
Favourable Opinion