Real World Evidence Alliance at Leeds: Multiple Myeloma 1.0
Research type
Research Study
Full title
REAL-MM 01: A Real World Evidence Alliance at Leeds Study to Evaluate Clinical Characteristics, Outcomes and Healthcare Costs in Multiple Myeloma.
IRAS ID
277141
Contact name
Geoffrey D. Hall
Contact email
Sponsor organisation
Leeds Teaching Hospital NHS Trust
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
This is a study based at the Leeds Cancer Centre at Leeds Teaching Hospitals Trust (LTHT) looking retrospectively at outcomes in patients with multiple myeloma (MM), a cancer of white blood cells. Clinical trials results often do not reflect the average patient who attends a clinic. In a typical clinic, patients are older, less fit and have more medical problems than patients who are enrolled into a clinical trial. New drugs are brought into widespread clinical use based on the results of these highly selective clinical trials. It is not known how trial results translate into general clinical practice and if trial treatments are as effective in the real world as published literature suggests. We will be looking at what happens to patients who have treatment for MM including how effective anti-cancer treatment is (chemotherapy and targeted therapies) at shrinking the cancer, how long the treatment works and how long patients live. We will also look at patient co-morbidities, surgical interventions and radiotherapy use. This study will also look at costs associated with healthcare utilisation eg. investigations, outpatient attendances, in patient admissions, use of interventions and length of hospital inpatient stay. The patients will be analysed according to cancer cancer subtypes e.g. by stage or cytogenetic abnormalities. This data is routinely collected within PPM, the electronic patient record developed by LTHT and in use across Yorkshire. Irreversibly de-identified data will be extracted from PPM for analysis. The data will provide real world evidence of cancer patient outcomes which will help to shape and improve the ongoing care of this patient group. It is envisaged that this project will lead to publications within peer reviewed journals and potentially onto further research projects.
REC name
London - City & East Research Ethics Committee
REC reference
20/LO/0276
Date of REC Opinion
6 Mar 2020
REC opinion
Favourable Opinion