Real time LDI to measure gastric perfusion during oesophagectomy

• Research type

  Research Study

• Full title

  A pilot study to assess the feasibility and reliability of real time laser doppler imaging to measure changes in gastric perfusion during oesophagectomy for oesophageal cancer.

• IRAS ID

  122884

• Contact name

  Elizabeth Bruna

• Sponsor organisation

  Guy's and St Thomas' Foundation NHS Trust

• Duration of Study in the UK

  0 years, 3 months, 28 days

• Research summary

  The overall aim of the study is to determine the feasibility and reliability of a laser doppler imaging device to measure changes in perfusion of the stomach during surgery (oesophagectomy) performed for oesophageal cancer . After excision of the oesophagus the stomach is fashioned into a narrow tube (gastric conduit) to replace oesophagus and is sutured to the remaining eosophagus (anastomosis) either in the neck or the thoracic cavity. Inadequate perfusion in the gastric conduit is a major factor contributing to anastomotic complications after surgery. These complications, anastomotic leak and stricture, are a significant cause of morbidity, mortality and poorer oncological outcome. The study uses a medically licensed device (ce marked) used within its market intended purpose for measuring perfusion in human tissues and is routinely used in clinical practice to measure tissue perfusion (blood flow), burn depth and microcirculation in hand surgery. Adult patients with oesophageal cancer undergoing potentially curative surgery are eligible for inclusion in the study. Surgery is performed at Guy's and St Thomas' Foundation NHS Trust by a team of specialist consultant upper gastro-intestinal surgeons of whom the investigators are active members. Participants in the study will be followed up as part of their routine post operative care which is usually for 5 years. For the purposes of the study, data will be recorded from follow up at 1 month post operatively.

• REC name

  HSC REC B

• REC reference

  15/NI/0087

• Date of REC Opinion

  6 May 2015

• REC opinion

  Further Information Favourable Opinion