Reading networks in the developing brain
Research type
Research Study
Full title
Reading networks in the developing brain
IRAS ID
179291
Contact name
Chris Clark
Contact email
Sponsor organisation
UCL Institute of Child Health
Duration of Study in the UK
1 years, 5 months, 31 days
Research summary
The study will investigate whether the cognitive dysfunction experienced in children with benign partial epilepsy of childhood with centrotemporal spikes (BECTS) is related to structural and functional abnormalities in specific brain regions. An MRI technique known as diffusion imaging and resting state EEG-fMRI techniques in BECTS and together with cognitive testing focused on language abilities will be used to investigate whether the cognitive dysfunction experienced in BECTS is related to structural and functional abnormalities in specific brain regions. The expected outcome of this study could be informative for the clinical setting. If the link between abnormalities in the structural and functional connectivity of the brain and cognitive dysfunction are established, future application of the proposed imaging methods could be made at early time points in the clinical course of the condition to assess the risk of developing cognitive problems or alternatively to understand how permanent cognitive deficits arise from remodeling induced by repetitive transient epileptic events.
REC name
London - Chelsea Research Ethics Committee
REC reference
15/LO/1759
Date of REC Opinion
27 Jan 2016
REC opinion
Further Information Favourable Opinion