REACTOr
Research type
Research Study
Full title
Resistance training in cardiac patients with a Chronic Total Occlusion (REACTOr)
IRAS ID
259510
Contact name
Thomas Nickolay
Contact email
Sponsor organisation
Hull University
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 1 months, 1 days
Research summary
A coronary chronic total occlusion refers to the long term complete blockage of a blood vessel supplying the heart. Exercise is now regarded as a staple component of cardiac rehabilitation. Exercise can be divided into aerobic; namely walking and running, and resistance based, such as; lifting, pulling, and pushing. Tasks associated with daily living probably stresses the skeletal muscles more then the heart and lungs, therefore increasing strength is an important part of rehabilitation in cardiac patients. However, resistance-based exercise has not previously been tested in patients with a completely blocked blood vessel. This study will evaluate whether prescribing an 8 week resistance-based exercise intervention in this population is feasible. Secondly, we will investigate whether the physiological changes that occur after training influence the patients underlying angina, quality of life, and muscle strength.
Participants will make 2 visits to our laboratories to establish baseline measures of cardiovascular and skeletal muscle strength prior to an 8 week resistance-based training intervention. These baseline measures will be repeated after the intervention to determine if any change has occurred. Testes performed during these 4 visits will include 2 symptom limited maximal exercise tests using a stationary bike for approximately 8-12 minutes. The bikes` resistance will gradually increase until participants choose to stop or the researcher ends the test. Participants will wear a mask that collects exhaled breath for testing, and will be connected to an electrocardiogram (heart trace monitor) and blood pressure cuff for monitoring throughout the test.
The participants’ will also perform maximal strength testing using dumbbells and cable pulley machine. Participants will perform 5 maximal weight reps in multiple upper and lower body exercises. Throughout the testing electromyography (EMG) will be used to measure the electrical activity in the working muscle. Participants will also have continuous blood pressure and heart rate measured.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
19/YH/0405
Date of REC Opinion
5 Dec 2019
REC opinion
Favourable Opinion