REACT-AMI study
Research type
Research Study
Full title
REACT-AMI (REadmissions, Adverse Complications and ouTcomes following Acute Myocardial Infarction) Study
IRAS ID
234587
Contact name
Mamas Mamas
Contact email
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
Acute myocardial infarction (hereafter called “heart attack” throughout this application) remains a leading cardiovascular cause of morbidity and mortality worldwide and is the commonest manifestation of coronary heart disease. It is estimated that almost half (46%) of the cardiovascular disease-related deaths are due to heart attacks in the UK. The acute survival of patients following a heart attack has improved significantly over the past decade due to advances in pharmacological and invasive therapies. However, the population demographics is continuing to change with the average age of patients increasing, resulting in increasingly multimorbid population at greater risk of complications, readmissions and mortality.
There is limited information around the incidence and type of post discharge complications of heart attacks, readmission and their association with long term outcomes. We hypothesise that although the risk of mechanical complications following a heart attack have reduced over time, there is increased risk of ischemic and bleeding complications in this cohort due to changes in population demographics and evolving pharmacological treatments.
This work is therefore aimed to assess the incidence and relevance of post discharge complications and unplanned readmissions. We will study predictors and geographical variations between different types of complications and finally develop prognosis tools to estimate the risk of these complications and unplanned readmissions using a large scale longitudinal MINAP (Myocardial Infarction National Audit Project) data extract of all recorded heart attack cases in England and Wales from 1st January 2005 to 31st March 2020, linked with Hospital Episode Statistic (HES) and Office of National Statistics (ONS) mortality data.REC name
Wales REC 5
REC reference
20/WA/0312
Date of REC Opinion
25 Nov 2020
REC opinion
Favourable Opinion