Rapid Shallow Non-Invasive Ventilation for Radiotherapy
Research type
Research Study
Full title
Utilising non-invasive ventilatory techniques employed at higher frequency and lower amplitude breathing patterns in conscious, unsedated patients, to assess tolerability and the potential dosimetric benefits in radiotherapy.
IRAS ID
231019
Contact name
Nicholas West
Contact email
Sponsor organisation
Northern Centre for Cancer Care
Clinicaltrials.gov Identifier
8925, Trust R&D Ref:
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
In radiotherapy, accounting for motion due to respiration ensures lung tumours are encompassed by the correct dose in all points of the breathing cycle but also increases the volume of the healthy tissue treated. The dose must be limited to this large volume of healthy tissue to reduce side effects, in doing so, the effectiveness of the treatment is compromised. In addition, if breathing motion is large the volume of normal tissue irradiated increases and high dose radiotherapy is not suitable and the patient may miss out on an effective treatment regime.
Rapid shallow breathing, which can be achieved with a simple non-invasive ventilator, has been proven locally with healthy volunteers to give more predictable and smaller chest and abdomen movements. If this is proven to be feasible with patients referred for radiotherapy, it is highly probable that more targeted radiotherapy will be achieved. This study will investigate the tolerability of this technique in a clinical setting with relevant subjects; patients referred for high dose radiotherapy.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
18/NE/0327
Date of REC Opinion
2 Jan 2019
REC opinion
Further Information Favourable Opinion