RAPID-RT study (use of patient data)
Research type
Research Study
Full title
A study to develop the rapid-learning methodology and evaluate its clinical acceptability to monitor clinical outcomes after radiotherapy in lung cancer patients
IRAS ID
317619
Contact name
Corinne Faivre-Finn
Contact email
Sponsor organisation
The Christie NHS Foundation Trust
Duration of Study in the UK
3 years, 11 months, 31 days
Research summary
The main aim of the RAPID-RT study is to develop a novel rapid-learning methodology using only real-world data to evaluate patient outcomes following evolutionary changes to standard of care radiotherapy for lung cancer delivered at The Christie NHS Foundation Trust. This will be achieved using data collected on as many patients as possible treated at the Christie with non-SABR radiotherapy for stage I, II or III lung cancer including data on their cancer, radiotherapy treatment and outcomes. Informed opt-out consent will be used to include patient data.
No change to patients’ standard of care treatments will be made as part of this study, and patients will not have to make any additional visits to the hospital. Instead, we aim to analyse routine data, which is already collected during the course of cancer treatment. The rapid-learning methodology, once developed as part of this protocol, will be applied to investigate whether changes in standard of care practices at the Christie have led to measurable changes in patient outcomes.
An example of an analysis that will be performed under this study is the impact on patient outcomes of limiting radiation dose to the heart. We will test our methodology by comparing outcomes for patients treated under the old standard of care treatment with outcomes for patients treated under the new standard of care treatment. As other clinical changes in radiotherapy are introduced over the course of this study, we will apply the same developed methodology to see the effect of other changes in standard of care.
Additionally we will explore the acceptability by clinical teams of the rapid-learning methodology to measure changes in patient outcomes.
REC name
North West - Haydock Research Ethics Committee
REC reference
22/NW/0390
Date of REC Opinion
2 Feb 2023
REC opinion
Further Information Favourable Opinion