Rapid dEtectioN Of carbapenem resIstant oRganisms (RENOIR)
Research type
Research Study
Full title
Rapid dEtectioN Of carbapenem resIstant oRganisms (RENOIR) Development of a rapid Point of Care Molecular assay for the detection of carbapenem resistance genes in rectal swabs
IRAS ID
140243
Contact name
Simon D Goldenberg
Contact email
Sponsor organisation
Guy's & St Thomas' NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
The rapid spread of multidrug-resistant (MDR) bacterai means that we are reaching apoint wher common infections may become untreatable. MDR infections add considerable, avoidable costs to the healthcare system, requiring additional resources and result in greater disability and death compared with infections that are easily treatable.
Carbapanems are a group of broad-spectrum antibiotics which in many cases are our last effective defence against MDR bacterai. Carbapenemases are enzymes produced by bacteria to inactivate carbapenem antibiotics, and cause resistance. Almost half of hospital patients who get a carbapenemase producing organism (CPO) bloodstream infection die.
Many species of bacteria can acquire the genes for carbapenemases giving potential for rapid spread of resistance between bacteria. There have already been multiple outbreaks of CPOs in the UK and beyond with these strains becoming endemic in certain geographical pockets. International travel further increases the threat of these bacteria becoming established in this country.
National Policy states that healthcare facilities should test for CPOs to help select the most effective antibiotics for individual patients and so that infection control precautions can be implemented to reduce the spread to others (single room isolation, enhanced environmental cleaning, etc.)
Hospitals can identify CPOs by culturing plus conventional antibiotic sensitivity testing. However this method is not sensitive, is technically demanding and slow, taking at least 48 hours, by which time the bacteria may have spread to other patients and staff.
There is an unmet clinical need for rapid, accurate testing to identify CPOs. This proposal will address this need with a rapid test that can be performed close to the patient by a doctor or nurse.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
15/YH/0523
Date of REC Opinion
11 Jan 2016
REC opinion
Further Information Favourable Opinion