Randomised study comparing brain cooling in cardiac surgery.
Research type
Research Study
Full title
Randomised prospective study comparing patient temperature management and neurological outcomes of Coronary Artery Bypass Graft (CABG) surgery (with or without aortic valve replacement), using a conventional heart-lung machine, with or without additional trans-nasal brain cooling – ARcTIC 2.
IRAS ID
160417
Contact name
Paul D Waterworth
Contact email
Sponsor organisation
University hospital of South Manchester NHS Foundation Trust.
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Both temporary and permanent neurological dysfunctions are encountered following cardiac surgery. Delirium following aortic valve replacement + coronary artery bypass grafting (AVR+CABG) and coronary artery bypass surgery (CABG) in the elderly occurs in up to 50% of patients. Recent animal and clinical studies with intra-nasal cooling have suggested that effective brain cooling can be achieved via the trans-nasal route and that early onset of trans-nasal cooling has been beneficial in the emergency room setting in reducing brain damage in patients with cardiac arrest.
The aim of this study is to determine whether trans-nasal brain cooling commenced following anaesthesia and prior to the start of surgery, and during the re-warming phase to provide a slower rewarming of the brain, and prevent fever post rewarming, is effective in reducing cognitive and neurological dysfunction after surgery for aortic valve replacement combined with coronary artery bypass grafting and CABG alone.REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
15/NW/0249
Date of REC Opinion
16 Apr 2015
REC opinion
Favourable Opinion