Randomised comparison of iFR to FFR
Research type
Research Study
Full title
Prospective, multi-center, double blind, randomised study to test the safety of deferral of stenting in physiological non-significant lesions in a clinical population of intermediate stenoses using iFR and FFR
IRAS ID
139697
Contact name
Justin Davies
Contact email
Sponsor organisation
AHSC Joint Research Office, Imperial College London
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Narrowing of coronary arteries interferes with blood flow and can cause chest pain. But patients may have more than one narrowing and studies have shown that not all narrowings need to be treated. To identify the narrowings that need treating cardiologists sometimes quantify the extent of the narrowing by measuring fractional flow reserve (FFR, the ratio of the pressure in the aorta to the pressure downstream of the narrowing).This technique requires the administration of drugs that add cost and time to the procedure and in some countries are simply unavailable. As a result despite the clear health and healthcare costs benefits of FFR its use is limited to less than 5% of procedure. We have developed a new technique called the instantaneous wave-free ratio (iFR) that does not require the administration of drugs for its accurate assessment. It has been approved for use in this indication. This study aims to compare clinical outcomes of patients whose treatment has been guided by iFR to those whose treatment has been guided by FFR. If iFR is found to provide the same clinical outcomes as FFR its adoption will permit the clear benefits of this approach of identifying the coronary narrowings that really need treatment to be applicable to a much larger patient population and further improve healthcare costs.
REC name
London - Hampstead Research Ethics Committee
REC reference
13/LO/1725
Date of REC Opinion
11 Dec 2013
REC opinion
Further Information Favourable Opinion