Raman spectral imaging for liver tumours following liver surgery
Research type
Research Study
Full title
Raman spectral imaging for liver tumours following liver surgery
IRAS ID
284682
Contact name
Dhanwant Gomez
Contact email
Sponsor organisation
Nottingham University Hospitals NHS Trust
Duration of Study in the UK
2 years, 6 months, 1 days
Research summary
The aim of the proposed research is to develop a quick and reliable method for automated evaluation of tissue sections for residual tumour in histology specimens following liver surgery. This advanced technology will enable assessment of liver tumours and their resection margins following liver surgery. The technology is based on Raman spectroscopy (RS) and multivariate spectral analysis to produce 2-dimensional biochemical images that can reliably separate the spectral signal of liver tumours from surrounding normal tissue. We will investigate the ability of RS to distinguish between normal versus cancer in tissue blocks following liver surgery. If successful, this technique can then be investigated for intra-operative assessment efficacy to ensure that the resection margin of the tumour is clear (free of tumour cells), enabling this powerful procedure to be applied to all patients undergoing liver surgery for highest standard of care.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
20/EM/0184
Date of REC Opinion
6 Aug 2020
REC opinion
Further Information Favourable Opinion