Radiotherapy motion management using a CPAP device
Research type
Research Study
Full title
A proof-of-principle imaging study using Magnetic Resonance Imaging (MRI) to investigate patient compliance and comfort using a Continuous Positive Air Pressure (CPAP) device as a motion management technique
IRAS ID
268920
Contact name
Marianne Aznar
Contact email
Sponsor organisation
The University of Manchester
Duration of Study in the UK
0 years, 5 months, 30 days
Research summary
Background/importance – During normal breathing, the lungs and chest of the body move, leading to artefacts in magnetic resonance imaging (MRI) scans as consecutive images occur at differing phases of the breathing cycle. This results in errors in measurement of the size, shape, location and volume of the tumour, which has huge implications during radiotherapy delivery. Therefore there is a significant need to test methods to reduce breathing motion to enable use to more accurately see the tumour and therefore increase the accuracy of radiotherapy dose delivery.\n\nPurpose of study - This study will investigate patient comfort and compliance of using a CPAP machine (commonly used to treat sleep apnoea) while undergoing an imaging MRI scan to see whether use of the CPAP machine can reduce chest movement and therefore improve scan quality. \n\nStudy design - We will recruit 10 early stage lung cancer patients at the Christie Hospital undergoing stereotactic ablative radiotherapy (SABR) and image patients at 3 time-points during radiotherapy treatment (at the start, middle and end). Imaging at each time point will be performed both with and without a CPAP machine for direct comparison of the impact of the CPAP on tumour motion. Patients will be asked to complete an experience questionnaire at each imaging session to evaluate comfort. \n\nNo direct benefits to enrolled patient is expected.\n\nThe study is funded by the University of Manchester as part of their STFC Global Challenge Network+ in Advanced Radiotherapy Award. Grant Ref: ST/N002423/1. Patients will be recruited and imaged at the Christie Hospital.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
20/YH/0031
Date of REC Opinion
3 Feb 2020
REC opinion
Favourable Opinion