RADAR-2
Research type
Research Study
Full title
Role of Active Deresuscitation After Resuscitation-2: a pilot randomised controlled trial of conservative fluid management versus usual care in critical illness
IRAS ID
133620
Contact name
Jon Silversides
Contact email
Sponsor organisation
Belfast Health and Social Care Trust
Duration of Study in the UK
2 years, 5 months, 31 days
Research summary
Patients who are seriously ill in Intensive Care often receive a lot of fluid (water and salts) through drips as part of their treatment. Damaged blood vessels leak this fluid into tissues, and the normal mechanisms to get rid of extra fluid through the kidneys do not function well in this situation. This is often visible in hands and feet, but also present in lungs, bowels and other organs, where it reduces the flow of blood and oxygen. Our theory is that by reducing the amount of fluid given and by using drugs called diuretics and, if necessary, kidney dialysis to remove excess fluid from the body (a process called deresuscitation), we will help organs to work better and patients to have better outcomes.
We plan to carry out a pilot trial in which patients will be randomly assigned to two alternative regimens and the two groups of patients compared. In one group, we will restrict fluid given, and use diuretic drugs to remove fluid (deresuscitation). In the other group, we will treat patients as normal.The aims are to see if the deresuscitation regimen is (1) effective at removing excess fluid, and (2) safe for patients. We may also see an improvement in organ function and in some blood tests with deresuscitation, although we do not expect to prove which regiment is better using this small study alone. If deresuscitation is feasible and safe, we hope this will need to another, larger, study in the future to see if deresuscitation is effective in reducing organ failure and death.
REC name
HSC REC B
REC reference
17/NI/0192
Date of REC Opinion
20 Oct 2017
REC opinion
Further Information Favourable Opinion