Quantitative PD Neuroradiology MR Report
Research type
Research Study
Full title
Development of a Clinical Quantitative Neuroradiology MR Report for Parkinson's disease.
IRAS ID
354949
Contact name
Pushpsen Joshi
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
https://doi.org/10.17605/OSF.IO/KZDH4, OSFREGISTRIES; 182276, EDGE reference number
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Why?
This study aims to develop an automated report using advanced MRI techniques to measure factors such as iron, neuromelanin (dark intracellular pigment), and changes in brain volume, thereby tracking Parkinson’s disease over time and enabling better management. This MRI report would help differentiate Parkinson’s from other similar conditions and will enhance early diagnosis.
2. How is it of relevance and importance to the public?
Parkinson’s disease, the second most common neurodegenerative disorder, significantly affects quality of life with motor and non-motor symptoms. Parkinson’s disease is diagnosed by clinical evaluations that can delay treatment. A reliable MRI measure would enhance diagnosis, facilitate early intervention, reduce misdiagnosis, and support the development of new therapies in clinical trials.What?
We need volunteers who have a diagnosis of Parkinson’s disease to attend for a 90-minute visit. During the visit, the volunteer will have a 30-minute clinical evaluation of their symptoms and history, followed by an MRI scan of their brain, taking around 60 minutes.Who
We would like to recruit volunteers who have movement disorders at various stages (e.g. early, mid or later stages) as well as volunteers without movement disorders to help us compare the Parkinson’s MRI scan.Where?
The study will be conducted in the Lysholm Department of Neuroradiology in the National Hospital for Neurology and Neurosurgery.How, when?
The study will recruit volunteers until April 2027. Participants will need to visit the hospital for their MRI scan and clinical evaluation. You do not have to volunteer to join the study. If you choose to participate, you are free to withdraw from the study at any time without giving a reason. This would not affect the standard of care you receive.REC name
London - West London & GTAC Research Ethics Committee
REC reference
26/LO/0172
Date of REC Opinion
18 Mar 2026
REC opinion
Further Information Favourable Opinion