Quantitative imaging of GEP-NETs with 99mTc EDDA/HYNIC-TOC
Research type
Research Study
Full title
Quantitative imaging of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) with 99mTc.EDDA/HYNIC-TOC; optimisation of imaging parameters
IRAS ID
265273
Contact name
Katrina Cockburn
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
We are seeking to establish the most accurate method for quantitative imaging of neuroendocrine tumours (NETs) with a radioactive tracer known as 99mTc EDDA/HYNIC-TOC, or “Tektrotyd”.
Quantitative imaging, which allows clinicians to determine how much of a tracer has bound to a tumour, has become a useful tool in the treatment of many tumour types. It can aid in selection of the most appropriate treatment, allows accurate planning for radiotherapy with radioactive drugs, and demonstrates the progression of the disease more accurately than x-ray or MRI imaging alone.
Patients with NETs which have originated in the stomach, gut or pancreas (known as gastroenteropancreatic NETs, or GEP-NETs) often undergo imaging with Tektrotyd for diagnosis and staging. We think that performing quantitative imaging with the Tektrotyd will help in the treatment of patients with GEP-NETs.
To establish the most accurate technique for quantification, we plan to recruit three patients who are undergoing normal diagnostic imaging for GEP-NETs. Suitable patients will be identified at the multidisciplinary team meetings and will be approached by the investigators. Patients who agree to participate will undergo an additional nuclear medicine image and additional low radiation dose CT image compared to routine treatment. They will also have two 5ml blood samples taken which will be measured to determine how much radioactive tracer remains in the blood stream at different time points.
All procedures will take place in the Medical Physics department at the University Hospital Hartlepool on the day of the diagnostic imaging, and will extend the time the patient will be in the department from four-and-a-half hours to around five. At the end of this period, the patient will be free to go and there will be no additional follow-up. The acquired images and blood samples will then be anonymised and processed by the researcher.REC name
Wales REC 6
REC reference
20/WA/0116
Date of REC Opinion
17 Apr 2020
REC opinion
Favourable Opinion