Quantitative Fluorescence for Low Grade Glioma
Research type
Research Study
Full title
Intraoperative hyperspectral imaging for real-time quantitative fluorescence-guided surgery of low-grade glioma
IRAS ID
307291
Contact name
Jonathan Shapey
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
22/LO/0299, West London and GTAC
Duration of Study in the UK
0 years, 36 months, 0 days
Research summary
Brain tumour surgery for low-grade glioma (LGG) improves patient outcome and survival but is very challenging. Even with the most advanced surgical techniques it remains difficult to determine tumour from healthy brain tissue. Advanced surgical methods can use light (fluorescence) created by the tumour to guide surgery. However, in the case of LGG, hardly any fluorescence light is visible, and each surgeon may judge the location and amount of light differently. Recent smart camera systems have the potential to enhance the surgeon’s vision to more reliably identify tumour and healthy brain structures. Hyperspectral imaging (HSI) is one of the most promising of such technologies providing rich information that is invisible to the human eye and could provide accurate and detailed measurements of tumour fluorescence. Using HSI, this study aims to develop objective surgical guidance to provide detailed real-time tissue margin information during surgery providing a step-change for treating LGG patients.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
22/LO/0299
Date of REC Opinion
24 May 2022
REC opinion
Further Information Favourable Opinion