Quantitative Coronary Angiography in Coronary Heart Disease
Research type
Research Study
Full title
Absolute quantification of coronary & myocardial blood flow from coronary angiographic Xray image acquisitions - A comparison with Fractional Flow Reserve and Thermodilution Coronary Flow measurements.
IRAS ID
117142
Contact name
Mohan U Sivananthan
Contact email
Sponsor organisation
Leeds Teaching Hospitals NHS Trust
Research summary
Absolute Quantification of Coronary and Myocardial Blood Flow from X-ray Coronary Angiography performed in patients with Coronary Heart Disease – A comparison with pressure-derived Fractional Flow Reserve and flow-derived Coronary Thermodilution measurements.
Patients with symptoms related to Coronary Heart Disease often need treatment to improve the blood supply to the heart. Currently the decision as to the type of treatment required relies upon X-ray images identifying narrowings of the coronary arteries supplying the heart. Increasingly, information as to the amount of blood flowing to the heart is important to decide which type of treatment is recommended. Previous animal research studies have shown that it is possible to measure the amount of blood flow to the heart directly from X-ray images.
The aim of this study is to assess a novel X-ray imaging technique to measure blood flow to the heart during a procedure which widens the coronary artery at the site of a narrowing (Percutaneous Coronary Intervention - PCI). PCI requires the use of a fine wire (guide-wire) passed down the coronary artery in order to guide stents into position. Certain guide-wires may be used that allow measurement of coronary flow during PCI. The main aim of the study is to compare measurements by the X-ray technique with those from these special guide wires.REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
13/YH/0265
Date of REC Opinion
14 Oct 2013
REC opinion
Further Information Favourable Opinion