Quantitative biomarkers in MI
Research type
Research Study
Full title
Quantitative cardiovascular magnetic resonance imaging techniques for prediction of complications after acute myocardial infarction
IRAS ID
220657
Contact name
Erica Dall'Armellina
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
5 years, 6 months, 1 days
Research summary
Cardiovascular magnetic resonance (CMR) is the established gold standard technique clinically used to assess the composition of the heart muscle to distinguish viable versus non viable myocardium in patients with ischaemic heart disease and address treatment. A key determinant of the pump function of the heart is the complex architecture of the myocardium, comprised of muscle and connective tissue. In particular, this micro-structural architecture fundamentally defines both the electrical conductivity and shape of the heart. By using novel CMR techniques (i.e. diffusion tensor imaging), which allow imaging the changes in orientation of the fibres of the heart muscle, we aim to establish new acute predictors of long term LV remodelling, arrhythmias and long term events (MACE). The ultimate goal is to provide accurate imaging biomarkers and new prognostic scores to better guide therapies to reduce infarct size acutely and to minimize left ventricular (LV) remodelling and cardiac deadly arrhythmias.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
17/YH/0062
Date of REC Opinion
21 Apr 2017
REC opinion
Further Information Favourable Opinion