Quantifying total body perfusion using Oxygen-15 water PET
Research type
Research Study
Full title
Quantifying total body blood flow and perfusion using Oxygen-15 water PET in people with coronary artery disease. (QUANT-POW)
IRAS ID
357779
Contact name
Mark Thomas Macmillan
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
1 years, 5 months, 1 days
Research summary
Disease of the blood vessels of the heart is unfortunately very common. Often people who have heart disease, also develop problems in other organs such as the brain, kidneys or lower limbs. The reasons for this are not completely clear but could be caused by poor blood across the body. Previously it had been very difficult to assess blood flow to the brain and heart at the same time.
In Edinburgh a new imaging device called total body PET-CT scanner has made imaging the heart and other organs at the same time possible. This study uses this scanner to assess how blood flow to bodily organs change in heart disease.
Participants will undergo total body PET-CT using the radiotracer Oxygen 15 PET in addition to coronary artery CT both at rest and following cardiac stress induced using regadenason. In so doing we will be able to assess how organ perfusion changes under stress in people with coronary artery disease.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
25/EM/0277
Date of REC Opinion
19 Jan 2026
REC opinion
Further Information Favourable Opinion