Quantifying Plasma Refill During Ultrafiltration
Research type
Research Study
Full title
An investigation of transcapillary plasma refill during ultrafiltration in haemodialysis
IRAS ID
196826
Contact name
Nicos Mitsides
Contact email
Sponsor organisation
Manchester University NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Dialysis is essential for people with advanced kidney disease to maintain fluid balance. Dialysis removes fluid excess from the body through the blood circulation. However any fluid excess in these patients is spread across the body. Once fluid is removed from the blood circulation fluid from other parts of the body (such as the one that causes ankle swelling) moves back into the blood circulation to maintain a stable blood pressure. This is called blood refill. There tends to be a delay in blood refill and if the speed of fluid removal is much higher than the speed of blood refill the blood pressure drops making the patient feel unwell and causing harm to other organs in the body such as the brain and the heart. The speed of blood refill is different from person to person and can also change within a single dialysis session. Finding ways to predict the speed of blood refill and monitoring it in real time could prevent drops in blood pressure.
We would like to measure the speed of blood refill in 30 patients during their haemodialysis treatment. All consenting adults receiving their treatment at Central Manchester University Hospitals NHS Foundation Trust will be eligible to take part in the study. The measurements will be performed over the course of one haemodialysis session and will mainly utilise the blood volume-monitoring module of their haemodialysis machine. Added measurement will include body fluid composition using non-invasive techniques and blood sampling that will be performed before, during and after haemodialysis the participants haemodialysis needles. Blood samples will be tested for surrogate markers of the different parameters that can influence blood refill.
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
16/NW/0298
Date of REC Opinion
24 Jun 2016
REC opinion
Further Information Favourable Opinion