Quantification of Glioma Malignancy by MRI
Research type
Research Study
Full title
Quantification of Glioma Malignancy by MRI (Q-GliMa)
IRAS ID
159738
Contact name
Glyn Johnson
Contact email
Sponsor organisation
University of East Anglia
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
Gliomas are the most common primary brain tumour and the second leading cause of cancer death in children and young people. Despite years of research and major advances in the treatment of other tumours, gliomas are inevitably fatal. However, recent development of new treatments has resulted in significant increases in life expectancy. Effective use and efficient development of new treatments requires an accurate means of determining how aggressive tumours are. The aim of this project is to develop magnetic resonance imaging (MRI) methods that can be used to assess glioma aggressiveness.
Two key aspects of gliomas that determine their aggressiveness are their ability to stimulate the growth of new blood vessels to supply them with nutrients and the ability to infiltrate into the normal brain. We propose developing and assessing new MRI methods to measure the growth of blood vessels and to detect the presence of infiltrating tumour cells in normal appearing brain. Measurements using these techniques will be compared with both microscopic assessments of tumour aggressiveness and with rates of tumour progression.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
16/EE/0136
Date of REC Opinion
6 Jun 2016
REC opinion
Further Information Favourable Opinion