QS-CMR Study
Research type
Research Study
Full title
Quantitative Assessment of Coronary Artery Disease Severity using Cardiovascular Magnetic Resonance (CMR)
IRAS ID
219581
Contact name
Tim Lockie
Contact email
Sponsor organisation
Royal Free London NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Stable angina is the most common symptoms of coronary artery disease, causing chest pain or breathlessness on exertion. It is caused by narrowing in the arteries around the heart. Treatment options include implantation of stents, coronary artery bypass surgery (CABG) or tablets alone. Treatment decisions are based on the presence of ischaemia (dysfunction of heart muscle due to lack of blood supply).
We plan to study a new way of assessing ischaemia using cardiovascular magnetic resonance imaging (CMR) to assess the degree of reduction in blood flow to the heart muscle. We plan to compare this to fractional flow reserve (FFR), which is the gold standard for measuring ischaemia but is invasive.
We plan to recruit patients with stable angina who have been referred for a cardiac catheterisation to diagnose and/or treat (with stents) coronary artery disease. During the clinically indicated procedure, participants will undergo FFR measurements to assess blood flow in each of the three main coronary arteries. Patients will undergo a CMR scans before the procedure and 4-8 weeks after the procedure if a stent is implanted.
This information will allow us to validate this new non-invasive technique against an established invasive gold standard. Once developed, it would offer a new, safer way to assess the severity of coronary artery disease
REC name
London - Hampstead Research Ethics Committee
REC reference
17/LO/0500
Date of REC Opinion
24 Apr 2017
REC opinion
Favourable Opinion