QPiPAD 1.0
Research type
Research Study
Full title
Quantitative Perfusion Imaging of the Lower Limb in Peripheral Arterial Disease using Contrast Enhanced Perfusion Ultrasound, Arterial Spin Labelling Magnetic Resonance Imaging and Perfusion Angiography
IRAS ID
296958
Contact name
Jessica Broni-Tabi
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2022/03/77 medical research, UCL Data Protection Number
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Peripheral Arterial Disease (PAD) is the narrowing and blocking of the blood vessels that supply the legs and feet. It is a common and progressive condition that affects patients of all backgrounds and genders and is more common in people with other problems such as heart disease, high blood pressure and diabetes mellitus as well being linked to ageing. It can be a severe disease and in 20% of patients can lead to pain on walking short distances and 2% of people can lead to painful ulceration, constant pain and can lead to amputation of part or all of the affected leg.
We are researching 2 different types of new scanning techniques to measure the amount of blood that is circulating within the tissues of the leg and foot (known as tissue perfusion). We want to measure tissue perfusion in people both with and without PAD. This will help find a more sensitive method to diagnose PAD earlier and help identify those with worsening arterial narrowing before they develop ulcers. Measuring tissue perfusion will guide doctors with decision about what procedure can be performed to improve blood flow in people with PAD.
Patients with all degrees of PAD will be eligible to take part in this study. The study will take part at University College London and Royal Free Hospital. The research will run along side normal investigations and treatment for Peripheral Arterial Disease and the study period will be 2 years.
Participants will undergo an ultrasound scan of the lower leg with an injection of a special dye into a vein in the arm, as well as a magnetic resonance (MRI) scan of the same area. Scans will be performed before and after treatment of their narrowed blood vessels.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
23/EM/0008
Date of REC Opinion
24 Feb 2023
REC opinion
Further Information Favourable Opinion