Pulmonary Rehabilitation and Cardiovascular Risk in COPD
Research type
Research Study
Full title
Pulmonary Rehabilitation and Cardiovascular Risk in COPD
IRAS ID
213116
Contact name
John Hurst
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2016/08/46 , UCL Data Protection
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Chronic obstructive pulmonary disease (COPD) is a common smoking-related lung disease. Patients with COPD are at increased risk of developing cardiovascular disease such as heart attacks and strokes. A simple measurement called arterial stiffness is a good assessment of how likely people are to have cardiovascular disease, both in healthy populations and those with COPD. Aortic Pulse wave velocity (aPWV) measures arterial stiffness,
Pulmonary Rehabilitation (PR) - a 6 week supervised group exercise and education class - is an effective intervention in COPD to reduce symptoms, improve exercise performance and prevent exacerbations. However, the effect of PR on cardiovascular risk in COPD is controversial as two small positive studies suggested benefit and one larger study did not.
We have recently shown that cardiovascular risk is higher in those COPD patients who get the most infections (exacerbations). PR is an effective intervention for preventing COPD exacerbations. Logically, the exercise component would be expected to reduce cardiovascular risk too.
We want to identify which patients with COPD get cardiovascular benefit from a PR programme and why others do not. We propose to measure aPWV before and after PR. We will then classify participants as responders or non-responders defined as the presence or absence of a significant improvement in aPWV. We will be collecting demographic and clinical information including daily physical activity level and how effective the PR has been to enable us to identify the characteristics of patients who do, and do not achieve cardiovascular risk reduction in response to PR in COPD. This will inform on better design of PR programmes for people living with COPD.
REC name
London - Hampstead Research Ethics Committee
REC reference
16/LO/1974
Date of REC Opinion
22 Nov 2016
REC opinion
Favourable Opinion