Pulmonary Hypertension and measurement of exercise capacity
Research type
Research Study
Full title
Pulmonary Hypertension and measurement of exercise capacity remotely: the PERSPIRE study
IRAS ID
296131
Contact name
Carol Keen
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 10 months, 22 days
Research summary
Research Summary
Hospital based exercise tests are routinely used in patients with pulmonary hypertension to assess functional ability and disease progression over time. We are seeing a greater emphasis on non-face-to-face clinical assessments, where such tests cannot be conducted. It is important to identify alternative test which can be used to support clinical decision making.
Aim
To test the safety and efficacy of the 1-minute sit-to-stand test in patients with pulmonary hypertension.
Methods
A sample of 75 patients attending hospital appointments will carry out an Incremental Shuttle Walk Test, followed by a 1 minute sit-to-stand test after a 30 minute rest. Data will be analysed for safety and comparability between the 2 tests.Summary of Results
This study included 75 people with pulmonary hypertension who were in hospital for a normal clinical appointment. They all did a 1-minute sit-to-stand test, where they stood up and sat down as many times as the could within a minute.
We found that the test was safe in this group of people - no-one had any problems (such as become dizzy or passing out) during the test or immediately afterwards.
We found that the test results matched well with another exercise test, which is already well-used. So people who did well in the 1-minute sit-to-stand test also tended to do well on the other test, and people who performed poorly in one test tended to perform poorly in the other. We also found that the 1-minute sit-to-stand test was less physically demanding than the other test.
97% of people in the study said they would be happy to do the 1-minute sit-to-stand test at home.
These findings suggest that the 1-minute sit-to-stand test could be useful in the future, particularly to test people while they are at home, but we would need to carry out a larger study to be sure. We would also need to test if people can do the test at home safely.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
21/EE/0074
Date of REC Opinion
6 Apr 2021
REC opinion
Further Information Favourable Opinion