Pulmonary chloride transport in neonates with respiratory distress
Research type
Research Study
Full title
Pulmonary chloride transport in neonates with respiratory distress syndrome and subsequent development of chronic lung disease of prematurity
IRAS ID
245788
Contact name
Michael Eisenhut
Contact email
Sponsor organisation
Luton and Dunstable University Hospital NHS Foundation Trust
Clinicaltrials.gov Identifier
Not applicable, Not applicable
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Premature delivery is associated with a condition called respiratory distress syndrome that is breathing difficulties in newborn babies. We would like to find out why this is so we can improve treatment for this condition in newborns in the future. To find out more about what is going on in the lungs of newborns, who require breathing support with a ventilator machine we propose to analyse what is coming out of the lungs of newborn babies. We can do this without disturbing the newborn by analysis of fluid which condensates in the tubing which brings the air coming out of the lungs of the baby back to the ventilator machine. This air is filtered in a filter which is part of the tubing and this filter holds the fluid which condensates in the tubing. We want to measure electrolytes like sodium, potassium and chloride and an inflammatory marker called calprotectin, which is released by inflammatory cells. This will give us, together with a data collection on blood parameters collected routinely and measured in the baby’s urine, insight into the electrolyte transport in the lungs of the baby. Electrolyte movements in the lung are important for clearance of lung liquid. If there is an abnormality in electrolyte movements in the lungs it can cause fluid to accumulate causing respiratory distress and potentially chronic lung disease. We will compare newborns with and without subsequent development of chronic lung disease to help us understand the reasons for its development as well.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
18/WM/0157
Date of REC Opinion
10 Oct 2018
REC opinion
Further Information Favourable Opinion