Psychosis MRI Shared Data Resource (Psy-ShareD), V1
Research type
Research Database
IRAS ID
352347
Contact name
Paul Allen
Contact email
Research summary
Psychosis MRI Shared Data Resource
REC name
London - Dulwich Research Ethics Committee
REC reference
25/LO/0184
Date of REC Opinion
12 May 2025
REC opinion
Further Information Favourable Opinion
Data collection arrangements
Pre-existing MRI datasets are acquired from the following sources: 1) Anonymised KCL datasets that are currently in the LNDB MRI archive (REC reference: 033/03, London Camberwell St Giles, SLaM R&D Ref: R&D2003/110). The LNDB includes MRI datasets that have been acquired since 2002 and are stored on a secure server with controlled access. 2) Datasets are also acquired from UK and overseas partners via a data sharing agreements that require confirmation of ethical approvals for data reuse of anonymized data at the participating partner sites/institutions. No personal identifiers are used as all data is anonymised. Contributing sites share raw T1 images (anatomical MRI brain images)after defacing and removing any physical/personally identifying information from the MRI scans i.e. face stripping. Unique codes are then applied to each participant within a given dataset. The code denotes the site, the dataset number (where multiple datasets are shared) and participant number. No personal information is shared. Where anonymised dataset are acquired via a data sharing agreement, ethics must be in place for data reuse and sharing. Data is transferred to KCL via a secure and GDPR compliant data transfer portal that was developed by members of the Psy-ShareD team.
Research programme
Research that can underpin the development of new clinical tools that aid outcome prediction and stratification has clear benefits for clinicians and more importantly, for patients with SSD. Millions of people world-wide suffer from SSD, and currently, available treatment options have limited efficacy. Thus, it is of high strategic importance that we improve our understanding of the neurobiological mechanisms that underlie SSD to inform better detection, stratification, and treatment development. Researchers and academics, particularly early career researchers and doctoral students also benefit from the database. MRI datasets acquired in SSD populations are limited to a few institutions within the UK (and internationally), so providing access to these datasets will benefit the schizophrenia research community in general. Our plans to expand and develop the resource will have global impact within the field of research and will increase capacity for new knowledge.
Research database title
Psychosis MRI Shared Data Resource
Establishment organisation
King's College London
Establishment organisation address
Strand
London
WC2R 2LS