Pseudomonas study

• Research type

  Research Study

• Full title

  Comparison of treatment options for Pseudomonas aeruginosa bacteremia, a multisite retrospective study

• IRAS ID

  187463

• Contact name

  Alasdair MacGowan

• Contact email

  alasdair.macgowan@nbt.nhs.uk

• Sponsor organisation

  North Bristol NHS Trust

• Duration of Study in the UK

  2 years, 2 months, 31 days

• Research summary

  Blood Stream Infections with a bacteria called P. aeruginosa (PA) is a common clinical occurrence and is associated with high likelihood of death. There is no agreement on the best antibiotics for the treatment of this type of infection. The most difficult decision for the doctor treating the infection is whether to use one antibiotic to treat the infection or a combination of drugs. Another difficulty is whether one drug e.g. ceftazidime is better than another e.g., anti-pseudomonal penicillin.
  This is a multisite retrospective observational study to try to answer both these questions. We will include all adult patients hospitalized during the years 2009-2015 who were diagnosed with a blood stream infection caused by P. aeruginosa. We will include only one episode per patient.
  We will look at survival at 30 days. We will also look at other clinical outcomes eg how long the patient is in hospital and any side effects of taking the antibiotics.
  The main aim of the research is to see if we can identify the safest, most effective antibiotics to treat this type of infection

• REC name

  North West - Preston Research Ethics Committee

• REC reference

  15/NW/0768

• Date of REC Opinion

  16 Sep 2015

• REC opinion

  Favourable Opinion