Pseudo-obstruction assessment with MRI
Research type
Research Study
Full title
A case-control study of the gastrointestinal response to a liquid test meal in chronic intestinal pseudo-obstruction, using magnetic resonance imaging
IRAS ID
269336
Contact name
Maura Corsetti
Contact email
Sponsor organisation
University of Nottingham
Clinicaltrials.gov Identifier
000, N/A
Duration of Study in the UK
1 years, 0 months, 30 days
Research summary
People with chronic intestinal pseudo-obstruction (CIPO) have problems digesting their food properly, due to a problem in their gut nerves or muscle. There are not many good tests to assess how a patient’s stomach and bowels are working. Finding out more is the first step in developing a standardised clinical test using MRI to provide a faster diagnosis than is currently possible. Magnetic resonance imaging (MRI) scans allow us to see inside the abdomen. Scans are not painful or harmful and are therefore ideal for repeated measurements. By scanning participants both before and after a test drink we can see exactly how their digestion is working.
We are inviting 16 people who are at least 16 years old, 8 who have CIPO and 8 with chronic constipation, so we can compare the images. Participants will come in for one half day of scanning. We will take a total of 8 scans of their abdomens, every half hour. Participants will also fill in symptom questionnaires at every scan, for example if they feel bloated or have any abdominal pain. Each scan will take about 15 minutes and will require short breath holds. Participants will be able to get out of the scanner at any time point if they feel the need to.
Participants will arrive fasted in the morning and will receive a test drink (a milk-based drink used as an oral nutritional supplement) right after the first scan. All participants will be asked to pause some of their usual medication that has a direct influence on digestion for 24h before the scan day and during the ~4h of the study.
Our primary outcome is peak small bowel motility, which we hypothesise to be less active in people with CIPO. Other outcomes include gastric volume, small bowel water content and distribution, peak gastric motility, and gastro-intestinal symptoms.REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
19/EM/0323
Date of REC Opinion
29 Nov 2019
REC opinion
Further Information Favourable Opinion