Proteonomic effects of metformin on myocardial ischaemia-reperfusion
Research type
Research Study
Full title
A case-control investigation of the proteomic effects of metformin on the myocardial response to ischaemia-reperfusion injury
IRAS ID
153200
Contact name
Neil Howell
Contact email
Sponsor organisation
Queen Elizabeth University Hospitals Birmingham Foundation Trust
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
All surgery which uses a heart lung machine to allow the heart to be stopped during the operation causes a degree of damage to the heart. In many patients this results in a decreased volume of blood being pumped per minute by their heart when it is restarted. In turn this causes a poor supply of nutrients and oxygen to other organs, therefore damaging them. Ultimately this negatively impacts upon short and long term survival, as well as future function.
This study aims to examine how the response to this injury of heart cells differs in patients taking metformin, a drug commonly used to treat diabetes, compared to those who do not. Specifically it will look at the difference in the levels of certain proteins produced by these heart cells. It is hoped that a better understanding of this response will help to find ways to reduce damage incurred to the heart during heart surgery.
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
15/WM/0273
Date of REC Opinion
16 Sep 2015
REC opinion
Further Information Favourable Opinion