ProteinEX
Research type
Research Study
Full title
Impact of plasma exchange on the elimination profile of plasma proteins
IRAS ID
260322
Contact name
Pratima Chowdary
Contact email
Sponsor organisation
Royal Free London NHS Foundation Trust
Duration of Study in the UK
1 years, 6 months, 0 days
Research summary
Plasma exchange is used to treat diseases caused by pathogenic antibodies or other macromolecules found in the plasma, or more rarely by albumin-bound small molecules (drugs or toxins) that remain predominantly intravascular. In this procedure, blood is filtered to spun and plasma removed. The removed plasma can be replaced with plasma from donors or albumin, a blood protein.
The aim of this is study is to evaluate the impact of serial plasma exchange with and without plasma replacement on the plasma proteins. The plasma proteins of interest in this study are proteins of the coagulation system, that help stop bleeding, antibodies that are important for immune system and responsible for disease, chemical messengers that can cause inflammation or identify inflammation. The information gathered will provide a scientific basis for identifying the ideal duration of exchange and need for replacement therapy with coagulation proteins and immunoglobulins.
REC name
London - Hampstead Research Ethics Committee
REC reference
19/LO/0420
Date of REC Opinion
30 May 2019
REC opinion
Further Information Favourable Opinion