Prospective cross-sectional analysis of fresh frozen adenomas

• Research type

  Research Study

• Full title

  Prospective cross-sectional study to identify gene/RNA expression differences and genetic/molecular age in small (<10mm), medium (>10mm <20mm) and large (>20mm) sized colorectal adenomatous polyps: Polyp PROGRESSion

• IRAS ID

  244440

• Contact name

  Anisha Sukha

• Contact email

  anisha.sukha@nhs.net

• Sponsor organisation

  London North West University Healthcare NHS Trust

• Duration of Study in the UK

  10 years, 0 months, 2 days

• Research summary

  This is a prospective cross-sectional study to identify gene and RNA expression and genetic/molecular correlates across small (<10mm), medium (>10mm <20mm) and large (>20mm) sized colorectal adenomatous polyps.

  Fresh frozen tissue will be collected from adenomas and the DNA will be extracted from multiple sites (via micro-dissection). Next generation sequencing involving whole-genome sequencing panels will be used to determine the genotypes (and expression profiles) of these adenomas.

  The aim of this work is to improve the prediction of future colorectal cancer risk, following the complete excision of an adenoma. This study will determine molecular markers, which can be used for clinical risk stratification.

• REC name

  London - Central Research Ethics Committee

• REC reference

  18/LO/0875

• Date of REC Opinion

  7 Jun 2018

• REC opinion

  Further Information Favourable Opinion