Progression of Arterial & Cardiac disease in Kidney patients Extended
Research type
Research Study
Full title
Progression of Arterial and Cardiac disease in Kidney patients and controls - An extended study (PACK-Extended)
IRAS ID
268505
Contact name
Debasish Banerjee
Contact email
Sponsor organisation
Joint Research & Enterprise Office, St George's University of London
Duration of Study in the UK
0 years, 8 months, 1 days
Research summary
Chronic Kidney Disease (CKD) affects 10-15% of the general population. CKD patients suffer from higher risks of heart attacks and strokes. The exact nature of why there is an increased risk is unknown. We have, through a previous study, demonstrated in patients in different stages of CKD and kidney transplant patients have highly abnormal blood vessel reactivity, thickened blood vessel walls, and atherosclerosis (furring) within the blood vessel. Although we know inflammation causes the abnormal blood vessel reactivity, which in turn causes the atherosclerosis. No study has examined the natural and long-term progression of blood vessel reactivity, blood vessel wall thickness, and furring of blood vessels in CKD and transplant patients.
This study hopes to look at the natural progression of these blood vessel parameters, the reactivity, wall thickness, and furring of the blood vessels. We will be looking at these parameters by measuring Brachial Artery Flow Mediated Dilation (Ultrasound scan on the arm), carotid and brachial intima-media thickness (Ultrasound scan on arm and neck), carotid-femoral wave velocity (a pressure probe placed on neck and groin), ankle-brachial index (blood pressure measurements on arm and leg), 12-lead electrocardiogram (heart tracing) and blood tests. As we will recruit patients who have previously participated within the Progression of Atherosclerosis in Chronic Kidney Disease (PACK) study, we will evaluate the changes in these parameters that occurred over the 1-2 years between PACK and this study. No new patients will be recruited into this study. All the examinations on research participants will be completed within a day in the Vascular Laboratory at the Cardiovascular Sciences Research Centre of St George’s University of London.
This new information on the natural progression of blood vessel parameters may help guide treatment in reducing the risk of heart attacks and strokes of CKD patients in the future.REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
19/NW/0679
Date of REC Opinion
5 Nov 2019
REC opinion
Favourable Opinion