Prognostic markers in kidney transplantation
Research type
Research Study
Full title
A study designed to investigate the donor and recipient factors that affect outcomes after kidney transplantation
IRAS ID
178119
Contact name
Kourosh Saeb-Parsy
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust & the University of Cambridge
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
Kidney transplantation is the optimal treatment for patients with end-stage renal disease and results in substantial benefit to recipients compared to remaining on dialysis. This includes reduced morbidity, a better quality of life, longer life-expectancy and reduced healthcare costs. The availability of this life-saving treatment, however, is limited by a relative shortage of kidneys that are suitable for transplantation. The shortage of organs is compounded by the failure of many kidneys early or late after transplantation due to poorly understood reasons, which include ischaemia-reperfusion injury, disease recurrence, rejection and drug toxicity. Consequently, patients spend prolonged periods on the kidney transplant waiting lists, and many die or are removed from the waiting list without being transplanted, or are never listed for transplantation. The study aims to investigate the cellular mechanisms of ischaemia-reperfusion injury, the immunological response to transplantation, and to identify prognostic markers for graft and patient outcomes. The study involves taking a limited number of samples of tissue, blood and urine before and after transplantation. The samples will be analysed using a panel of state-of-the-art assays and correlated with donor and recipient demographics and outcomes. It is anticipated that the study will enable the investigators to identify donor and recipient factors that are of prognostic value for graft and recipient outcomes after kidney transplantation.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
15/EE/0275
Date of REC Opinion
10 Sep 2015
REC opinion
Unfavourable Opinion