Profiling T Cell Responses During Dengue Infection
Research type
Research Study
Full title
Profiling T cell responses during dengue infection at a single-cell level
IRAS ID
230608
Contact name
Sarah Teichmann
Contact email
Sponsor organisation
Wellcome Trust Sanger Institute
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Dengue virus (DV) infection is a major health problem worldwide with currently no specific treatment. T cells are specific cells in the human immune system that are key players in protecting the body by killing off the DV infected cells. However T cells can secrete pro-inflammatory mediators and activation can lead to increased inflammation and result in severe symptoms. A better understanding of T cell response to dengue infection is crucial in the development of an effective treatment. In this study we aim to study the T-cell responses from blood previously collected from individuals with DV infection. T cells within the blood will be sorted and sequenced using single-cell RNA sequencing and the gene expression profiles compared across patients with differing severity of dengue infection. We aim to explore the pattern of T cell responses associated with DV protection and severity and hope that this will lead to a better understanding of T cell response to DV infection. Ultimately this improved understanding will hopefully lead to better preventative or therapeutic approaches with DV infection.
REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
17/LO/1587
Date of REC Opinion
8 Sep 2017
REC opinion
Favourable Opinion