Processing human immune cells in a novel bioreactor

• Research type

  Research Study

• Full title

  Processing human immune cells in a novel bioreactor for the use in basic science and cell therapies

• IRAS ID

  360305

• Contact name

  David Coe

• Contact email

  david@coedbio.co.uk

• Sponsor organisation

  CoED Biosciences

• Duration of Study in the UK

  4 years, 6 months, 25 days

• Research summary

  We have developed an in vitro tissue culture device called the CoED, that can be used to purify, functionalise and expand immune cells from blood and tumour biopsies.
  In this study we will use the CoED to purify, activate and functionalise different immune cells from different tissue biopsies, including blood and tumour. The immune cells we produce, especially T-cells will be tested for their number, viability and functional ability to kill tumour cells. In some cases immune cells will be genetically modified during the process to create experimental cell therapies such as CAR-T. To further our product towards translational applications we will purify immune cells from human blood products and tumour biopsies to confirm the feasibility of translating our technology to the clinic. We will apply to the local Welsh Blood Service or NHS-BT service and/or Anthony Nolan for umbilical cord and blood products and to the NHS and HTA registered tissue banks for tumour biopsies.

• REC name

  Yorkshire & The Humber - Bradford Leeds Research Ethics Committee

• REC reference

  25/YH/0188

• Date of REC Opinion

  9 Sep 2025

• REC opinion

  Favourable Opinion