PROCAS – Lifestyle Breast Cancer Prevention Feasibility Study
Research type
Research Study
Full title
Prevention of Cancer at Screening: Lifestyle Prevention (PROCAS - Lifestyle Prevention) Feasibility Study Does personalised information about risk of cardiovascular disease and diabetes enhance uptake and adherence to a weight loss programme amongst women who receive breast cancer risk feedback in the NHS Breast Cancer Screening Programme?
IRAS ID
160974
Contact name
Michelle Harvie
Contact email
Sponsor organisation
University Hospital of South Manchester (UHSM)
Research summary
Excess weight and poor lifestyle are linked to risk of breast cancer and other diseases including cardiovascular disease (CVD), diabetes, dementia and ten other cancers. Currently the NHS has no weight loss or lifestyle services aimed to reduce risk of breast cancer, and NHS approaches to weight reduction and lifestyle change for prevention of other diseases are not particularly effective.
The NHS National Breast Screening Programme (NHSBSP) is a logical place to target the lifestyle prevention of breast cancer since it has a large coverage of women (70% of women aged 47 to 73 years), and includes women who are already engaged in their health and specifically with breast cancer. Our lifestyle breast cancer prevention research programme aims to determine the best way to engage women in the NHSBSP with weight reduction and healthy lifestyle to reduce their risk of breast cancer and other diseases.
120 overweight women currently enrolled on the PROCAS Study will be randomly assigned to a weight loss / lifestyle programme with either:
1. A standard care group (n = 40)
A reminder their individual breast cancer risk and information that weight loss of >5% and lifestyle change can reduce this risk by 25%-30%. They will receive general (not personalised) information on the likely reductions in risk of other diseases with > 5% weight loss/ lifestyle change .2. An NHS health check group (n = 80)
As above but they will also receive an NHS health check and personalised information on their risk of developing cardiovascular disease and Type 2 diabetes. This group will be informed that weight loss of >5% and lifestyle change can reduce their risk of breast cancer by 25%- 30%, their risk of diabetes by 60% and CVD by 30%.All participants are seen at baseline, three and six months.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
14/WM/1088
Date of REC Opinion
9 Sep 2014
REC opinion
Further Information Favourable Opinion