Probiotics for the prevention of AAD and CDAD

  • Research type

    Research Study

  • Full title

    Probiotics for the prevention of Antibiotics associated diarrhoea and Clostridium difficile associated diarrhoea

  • Contact name

    Neil Haslam

  • Sponsor organisation

    Wrightington, Wigan and Leigh NHS Trust

  • ISRCTN Number

    N/A

  • Research summary

    Antibiotic associated diarrhoea (AAD) and Clostridium difficle associated diarrhoea (CDAD) are serious health care acquired infections occuring after antibiotic use. Probiotics have been proposed as a prevention and some studies have shown benefits. We want to establish whether giving the probitioc VSL#3 to a wide range of patients on antibiotics prevents the development of AAD and CDAD. 450 Patients in 4 hospitals will be recruited to receive either VSL#3 or a placebo. Outcome will be measured by how many develop AAD and CDAD, length of hospital stay and 30 day mortality.

  • REC name

    West Midlands - Black Country Research Ethics Committee

  • REC reference

    08/H1204/147

  • Date of REC Opinion

    28 Apr 2009

  • REC opinion

    Further Information Favourable Opinion